Erdosteine

Erdostin is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.

Erdosteine is a prodrug that is metabolised into N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.

The usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Erdosteine can be given up to 12 months or as directed by the physician. Erdosteine capsule may be taken with or without food.

It is contraindicated to patients who have hypersensitivity to Erdosteine. It should not be used in patients with creatinine clearance <25 ml/min, or with severe liver failure.

Common side effect is epigastric pain. Other side effects include headache, cold, taste alterations, nausea, vomiting, diarrhea, angioedema and other skin allergic reactions.

The use of Erdosteine in pregnant or breast-feeding women is not recommended.

It should be used with caution in mild liver failure. In that case, should not exceed a dose of 300 mg per day.

Keep in a dry place away from light and heat. Keep out of reach of children