Faropenem

Farobest tablet is indicated in the treatment of the following infections:

Lower respiratory tract infections : acute bronchitis, pneumonia, pulmonary suppuration.

Ear, nose, and throat (ENT) infections : otitis externa, tympanitis, sinusitis.

... Read more Farobest tablet is indicated in the treatment of the following infections:

Lower respiratory tract infections : acute bronchitis, pneumonia, pulmonary suppuration.

Ear, nose, and throat (ENT) infections : otitis externa, tympanitis, sinusitis.

Genito-urinary infections : pyelonephritis, cystitis, prostatitis, seminal gland inflammation.

Upper respiratory tract infections : pharyngitis, tonsillitis.

Skin and skin structure infections : pustular acne, folliculitis, contagious impetigo, erysipelas, lymphangitis, suppurative nail inflammation, subcutaneous abscess, hidradenitis (sweat gland inflammation), infective sebaceous cyst, chronic pyoderma, secondary infection of external wounds or surgical wounds.

Gynecological infections : adnexitis, bartholin gland inflammation.

Faropenem is a penem class of antimicrobial and has bactericidal activity against a variety of gm-ve, gm+ve and anaerobic bacteria. Faropenem is bactericidal, with a strong affinity for the high molecular penicillin binding proteins (PBPs) of the cell wall, which is essential for the multiplication of bacilli; it, thus, acts by inhibiting the cell wall synthesis. Faropenem shows broad antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. Faropenem is highly stable against various beta lactamases and binds preferentially to the PBPs, 2 and 1A, of Escherichia coli (E. coli).

Upper respiratory tract infections : 150 mg t.i.d., can be increased to 200 mg t.i.d. ENT infections : 200 mg t.i.d., can be increased to 300 mg t.i.d. Lower respiratory tract infections : 200 mg t.i.d., can be increased to 300 mg t.i.d. Skin and skin structure infections : 150 mg t.i.d., can be increased to 200 mg t.i.d. Genito-urinary infections : 200 mg t.i.d., can be increased to 300 mg t.i.d. Gynecological infections : 150 mg t.i.d., can be increased to 200 mg t.i.d.

Imipenem and Cilastatin sodium combination : It has been reported that in animal studies (rat), the concentration of Farobest in the blood increases. It is due to the obstruction of metabolic fermentation by cilastatin. Furosemide : It has been reported in animal studies (dog), that the kidney toxicity of Farobest increases. Sodium valproate : It has been reported that due to joint usage with carbapenem drugs (meropenem, panipenem and imipenem-cilastatin sodium) the concentration of valproic acid in the blood reduces, and there is a recurrence of epileptic fits.

Faropenem is contraindicated in patients with known hypersensitivity to any of the components of this product or to other drugs in the same class, or in patients who have demonstrated anaphylactic reactions to beta-lactams.

Common side effects of Farobest are Headache, Nausea, Vomiting, Stomach pain and Diarrhea.

Safety regarding therapy during pregnancy has not been established. In pregnant women or expectant mothers, the medicine should be given only if the benefit of the treatment is greater than the risks involved. Faropenem is excreted in human milk. Therefore, Faropenem should be given to nursing mothers only if the benefits outweigh the risks.

Farobest should be administered with caution in the following:

Patients with a past history of hypersensitivity to penicillin, cephem or carbapenem drugs.

Patients with a family history of atopy.

Patients with renal impairment. The dosage should be reduced or the interval between doses should be increased.

Geriatric patients.

Patients with poor oral intake or poor general state (since there are cases that show symptoms of vitamin K deficiency, proper monitoring should be done).

No specific information is available on the treatment of overdosage with Farobest. Intentional overdosing of Farobest is unlikely. In the event of an overdose, Farobest should be discontinued, and general supportive treatment given until renal elimination takes place.

Store Farobest at room temperature between 20°C to 25°C in its original package. Safely throw away any Farobest that is out of date or no longer needed. Keep Farobest and all medicines out of the reach of children. Protect from moisture.