GENERIC
Fluphenazine + Nortriptyline
Indications
- Permival is indicated in-
- Mild to moderate mixed anxiety/depression
- Emotional disturbance
- Sleep disorder
- Gastric problems
Pharmacology
Nortriptyline hydrochloride is a tricyclic antidepressant. Nortriptyline inhibits the uptake of norepinephrine and serotonin at nerve terminals. In contrast to its parent compound amitriptyline which is equally potent in inhibiting the uptake of norepinephrine and serotonin, Nortriptyline has a greater effect on norepinephrine reuptake than on serotonin reuptake. Fluphenazine is a tranquilizer of the phenothiazine type with piperazine side chain. Fluphenazine primarily acts as a neuroleptic drug whose main therapeutic effect is believed to reside in potent dopamine (specially D2) receptor antagonism.
Dosage and administration
Adults: One tablet 2 to 3 times daily.
Interactions
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Contraindications
- It is contraindicated in :
- History of gradual epilepsy or organic brain damage
- Blood dyscrasia
- Severe cardiac insufficiency
- Renal or liver damage
- Patients taking monoamine oxidase inhibitor (MAOI)
- Younger children
- Hypersensitivity to any component of the preparation
Side effects
Tardive dyskinesias have been reported in phenothiazine therapy; usually after prolonged courses given at doses adequately to control psychotic illness. Blood dyscrasia, Malignant Neuroleptic syndrome and sudden death have been reported rarely. Agranulocytosis is a rare but potentially fatal adverse effect of Nortriptyline Hydrochloride.
Pregnancy and lactation
The safety in human pregnancy has not been yet established. The use of this drug in lactation is not recommended, as it is excreted in breast milk.
Precautions and warnings
Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction, and in concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Clinical information is taken from the most complete brand listing (Permival); it applies to the active ingredient.
Brands of Fluphenazine + Nortriptyline
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Amival | Amico Laboratories Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.80per unit |
| 2 | Anflu | Alco Pharma Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.75per unit |
| 3 | Apresin | Beximco Pharmaceuticals Ltd. | Tablet | 0.5 mg+10 mg | ৳ 1.05per unit |
| 4 | Euphor | Biopharma Limited | Tablet | 0.5 mg+10 mg | ৳ 0.80per unit |
| 5 | Flutrip | General Pharmaceuticals Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.71per unit |
| 6 | Fresh | Nipa Pharmaceuticals Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.80per unit |
| 7 | Monitol | Skylab Pharmaceuticals Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.80per unit |
| 8 | Mudibak | Rephco Pharmaceuticals Ltd. | Tablet | 0.5 mg+10 mg | ৳ 0.75per unit |
| 9 | Norflu | ACME Laboratories Ltd. | Tablet | 0.5 mg+10 mg | ৳ 1.06per unit |
| 10 | Norzin | Aristopharma Ltd. | Tablet | 0.5 mg+10 mg | ৳ 1.05per unit |
| 11 | Permival | Opsonin Pharma Ltd. | Tablet | 0.5 mg+10 mg | ৳ 1.00per unit |
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.