GENERIC
L-Ornithine L-Aspartate
Indications
Hepaclin is indicated for the treatment of Hepatic Encephalopathy, Acute Liver Failure, Hyperammonemia due to Acute and Chronic Hepatitis, Fatty Liver, Alcoholic Liver damage, Adjunct to hepatotoxic drugs, Liver Cirrhosis, Post hepatitis convalescence etc.
Pharmacology
L-Ornithine L-Aspartate is a stable combination of two important endogenous Amino Acids, L-Ornithine and L-Aspartate. After administration, it quickly breaks down into L-Ornithine and L-Aspartate. L-Ornithine being a substrate of urea cycle, converts toxic ammonia into non-toxic urea which is eliminated via kidneys, helping the diseased liver to carry out its normal function smoothly (detoxification). The process lowers the elevated level of ammonia in blood (hyperammonemia) which is a common problem in most of the liver diseases. L-Aspartate is an essential component of citric acid cycle which liberates energy (ATP), and thus helps in regeneration of damaged liver cells.
Dosage and administration
Sachet : 1-2 sachets granules is dissolved in a large amount of fluid (e.g. in a glass of water or juice) and is taken orally 3 times a day during or after meals. Injection (Infusion Concentrate) : The recommended dose is up to 20 gm (4 ampoules daily). In case of loss of consciousness (pre-coma) and clouding of consciousness (coma) up to 8 ampoules within 24 hours, depending on the severity of the condition. Administrations-
L-Ornithine L-Aspartate infusion concentrate can be added to any of the conventional intravenous fluids (0.9% Sodium Chloride, 5% Dextrose and Ringer's lactate etc.)
The normal dilution rate is 1 ampoule per 100 ml of I.V. fluid. However, the dose should not exceed 6 ampoules per 500 ml infusion. The solution mixtures were stable up to 24 hours.
Infusion Rate: 5 gm/h at maximum.
Interactions
No data regarding the interactions of Hepaclin was found.
Side effects
Very rarely side effects like nausea and vomiting occur. These side effects are usually transient and do not necessitate the withdrawal of the drug.
Pregnancy and lactation
The administration in pregnancy and lactation should be avoided.
Precautions and warnings
Monitoring of serum and urinary urea levels at regular intervals should be done.
Storage
Store in a cool and dry place, keep away from light.
Clinical information is taken from the most complete brand listing (Hepaclin); it applies to the active ingredient.
Brands of L-Ornithine L-Aspartate
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Hepaclin | Incepta Pharmaceuticals Ltd. | Tablet | 150 mg | ৳ 18.00per unit |
| 2 | Hepaclin | Incepta Pharmaceuticals Ltd. | Oral Powder | 3 gm/sachet | Not listed |
| 3 | Hepaclin | Incepta Pharmaceuticals Ltd. | IV Injection | 5 gm/10 ml | Not listed |
| 4 | Hepagurd | Beximco Pharmaceuticals Ltd. | Oral Powder | 3 gm/sachet | Not listed |
| 5 | Hepalola | Total Herbal & Nutraceuticals | Tablet | 550 mg | ৳ 20.00per unit |
| 6 | HepaMerz | Mundipharma (BD) Pvt. Ltd. | Oral Powder | 5 gm/sachet | Not listed |
| 7 | Heparest | Everest Pharmaceuticals Ltd. | Oral Powder | 3 gm/sachet | Not listed |
| 8 | Heplol | Square Pharmaceuticals PLC | Tablet | 150 mg | ৳ 15.00per unit |
| 9 | Lola | Jenphar Bangladesh Ltd. | Oral Powder | 3 gm/sachet | Not listed |
| 10 | Oliver | Beacon Pharmaceuticals PLC | Tablet | 150 mg | ৳ 15.00per unit |
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.