Moxifloxacin Hydrochloride (Injection)

Moxilocin Injection is indicated for treating following infections in adults >18 years of age caused by designated, susceptible bacteria.

• Acute Bacterial Sinusitis
• Acute Bacterial Exacerbation of Chronic Bronchitis
• Community Acquired Pneumonia
• Skin and Skin Structure Infections: Uncomplicated and Complicated

Complicated Intra-Abdominal Infections.

The dose of Moxifloxacin is 400 mg once daily. The duration of therapy depends on the type of infection as described in following:

Acute Bacterial Sinusitis: 400 mg once daily for 10 days.

Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg once daily for 5 days.

Community Acquired Pneumonia: 400 mg once daily for 7-14 days.

Uncomplicated Skin and Skin Structure Infections: 400 mg once daily for 7 days.

Complicated Skin and Skin Structure Infections: 400 mg once daily for 7-21 days.

Complicated Intra-Abdominal Infections: 400 mg once daily for 5-14 days.

There are no data concerning an interaction of intravenous fluoroquinolones with oral antacids, sucralfate, multivitamins, didanosine, or metal cations. However, no fluoroquinolone should be co-administered with any solution containing multivalent cations, e.g., magnesium, through the same intravenous line. Quinolones, including Moxilocin, have been reported to enhance the anticoagulant effects of warfarin or its derivatives in the patient population. Although not observed with Moxilocin in predinical and clinical trials, the concomitant administration of a nonsteroidal anti-inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions. There is limited information available on the potential for a pharmacodynamic interaction in humans between Moxilocin and other drugs that prolong the QTc interval of the electrocardiogram. Sotalol, a Class III antiarrhythmic, has been shown to further increase the QTc interval when combined with high doses of intravenous (IV) Moxilocin in dogs. Therefore, Moxilocin should be avoided with Class IA and Class III antiarrhythmics.

Moxifloxacin is contraindicated in persons with known hypersensitivity to Moxifloxacin or other quinolone antibacterials.

Treatment with Moxilocin (oral, IV or sequential therapy) may cause some side effects. Common (>1%) side effects include headache, nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, dizziness, pyrexia and insomnia etc. Less common (0.1 to <1%) side effects include neutropenia, palpitations, tachycardia, bradycardia, vertigo, tinnitus, dry mouth, gastritis, edema, fatigue, malaise, hyperglycemia, anorexia, hyperlipidemia, hypoglycemia, dehydration, back pain and arthralgia etc.

Pregnancy Category C. Because no adequate or well controlled studies have been conducted in pregnant women, Moxifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Moxifloxacin is excreted in the breast milk of rats. Moxifloxacin may also be excreted in human milk. Because of the potential for serious adverse reactions in infants who are nursing from mothers taking Moxifloxacin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Fluoroquinolones, including Moxilocin, are associated with an increased risk of tendinitis and tendon rupture in all ages. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Fluoroquinolones have neuromuscular blocking activity and may exacerbate muscle weakness in persons with myasthenia gravis. Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Moxilocin, and may range in severity from mild diarrhea to fatal colitis.

Store below 25°C and protect from light. Avoid extreme heat and freezing. Keep out of reach of children.