17-hydroxycorticosteroids urine test

A 24-hour urine sample is needed. You will need to collect your urine over 24 hours . Your health care provider will tell you how to do this. Follow instructions exactly.

Your provider will instruct you, if necessary, to stop medicines that may interfere with the test. These may include: Birth control pills that contain estrogen Certain antibiotics Glucocorticoids

The test involves only normal urination. There is no discomfort.

17-OHCS is a product formed when the liver and other body tissues break down the steroid hormone cortisol. This test can help determine if the body is producing too much cortisol. The test may be used to diagnose Cushing syndrome . This is a disorder that occurs when the body has a constant high level of cortisol. The…

Normal values: Male: 3 to 9 mg/24 hours (8.3 to 25 µmol/24 hours) Female: 2 to 8 mg/24 hours (5.5 to 22 µmol/24 hours) Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test…

A higher than normal level of 17-OHCS may indicate: A type of Cushing syndrome caused by a tumor in the adrenal gland that produces cortisol Depression Hydrocortisone therapy Malnutrition Obesity Pregnancy A hormonal cause of severe high blood pressure Severe physical or emotional stress Tumor in the pituitary gland…

There are no risks with this test.

Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 15.