LAB TEST
Cortisol blood test
The cortisol blood test measures the level of cortisol in the blood. Cortisol is a steroid (glucocorticoid or corticosteroid) hormone produced by the adrenal gland . Cortisol can also be measured using a urine or saliva test.
How the Test is Performed
A blood sample is needed .
How to Prepare for the Test
Your health care provider will likely have you do the test early in the morning. This is important because cortisol level varies throughout the day. You may be asked not to do any vigorous exercise the day before the test. You may also be told to temporarily stop taking medicines that can affect the test, including:…
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
Why the Test is Performed
The test is done to check for increased or decreased cortisol production. Cortisol is a glucocorticoid (steroid) hormone released from the adrenal gland in response to adrenocorticotropic hormone (ACTH). ACTH is a hormone released from the pituitary gland in the brain. Cortisol affects many different body systems. It…
Normal Results
Normal values for a blood sample taken at 8 in the morning are 5 to 25 mcg/dL or 140 to 690 nmol/L. Normal values depend on the time of day and the clinical context. Normal ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your provider…
What Abnormal Results Mean
A higher than normal level may indicate: Cushing disease , in which the pituitary gland makes too much ACTH because of excess growth of the pituitary gland or a tumor in the pituitary gland Ectopic Cushing syndrome , in which a tumor outside the pituitary or adrenal glands makes too much ACTH Tumor of the adrenal…
Risks
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others. Other risks associated with having blood drawn are slight, but may include: Excessive…
References
Guber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods . 24th ed. Philadelphia, PA: Elsevier; 2022:chap 25. Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ,…
This is a summary. Read the full article at www.ucsfbenioffchildrens.org (reviewed 12/05/2023).
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.