LAB TEST

CSF total protein

CSF total protein is a test to determine the amount of protein in cerebrospinal fluid (CSF). CSF is a clear fluid that is in the space around the spinal cord and brain.

How the Test is Performed

A sample of CSF is needed [1 to 5 milliliters (ml)]. A lumbar puncture (spinal tap) is the most common way to collect this sample. Rarely, other methods are used for collecting CSF such as: Cisternal puncture Ventricular puncture Removal of CSF from a tube that is already in the CSF, such as a shunt or ventricular…

Why the Test is Performed

You may have this test to help diagnose: Tumors Infection Inflammation of the central nervous system Guillain-Barré syndrome Vasculitis Blood in the spinal fluid Multiple sclerosis (MS)

Normal Results

The normal protein range varies from lab to lab, but is typically 15 to 60 milligrams per deciliter (mg/dL) or 0.15 to 0.6 milligrams per milliliter (mg/mL). Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results. The…

What Abnormal Results Mean

An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area. A decrease in protein level can mean…

References

Deluca GC, Griggs RC. Approach to the patient with neurologic disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 26th ed. Philadelphia, PA: Elsevier; 2020:chap 368. Euerle BD. Spinal puncture and cerebrospinal fluid examination. In: Roberts JR, Custalow CB, Thomsen TW, eds. Roberts and Hedges' Clinical…

This is a summary. Read the full article at www.ucsfbenioffchildrens.org (reviewed 29/04/2023).

This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.