LAB TEST
Immunofixation - urine
Urine immunofixation is a test to look for abnormal proteins in urine.
How the Test is Performed
You will need to supply a clean-catch (midstream) urine sample. Clean the area around where urine leaves the body. Men or boys should wipe the head of the penis. Women or girls should wash the area between the lips of the vagina with soapy water and rinse well. Allow a small amount of urine to fall into the toilet…
How to Prepare for the Test
No special steps are necessary for this test.
How the Test will Feel
The test involves only normal urination. There is no discomfort.
Why the Test is Performed
This test is most often used to check for the presence of certain proteins called monoclonal immunoglobulins. These proteins are linked to multiple myeloma and Waldenström macroglobulinemia . The test is also done with a blood test to check for a monoclonal immunoglobulin in the serum.
Normal Results
Having no monoclonal immunoglobulins in the urine is a normal result.
What Abnormal Results Mean
The presence of monoclonal proteins may indicate: Cancers that affect the immune system, such as multiple myeloma or Waldenström macroglobulinemia Other cancers
Considerations
Immunofixation is similar to urine immunoelectrophoresis , but it may give more rapid results.
References
Castillo JJ, Treon SP. Waldenström macroglobulinemia/lymphoplasmacytic lymphoma. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice . 8th ed. Philadelphia, PA: Elsevier; 2023:chap 92. McPherson RA, Riley RS, Massey HD. Laboratory evaluation of immunoglobulin function and…
This is a summary. Read the full article at www.ucsfbenioffchildrens.org (reviewed 25/01/2023).
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.