Adinir

Adinir is indicated in- Community Acquired Pneumonia, Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis, Pharyngitis/Tonsillitis, Acute Bacterial Otitis Media and Uncomplicated Skin and Skin Structure Infections.

Cefdinir is a semisynthetic third generation oral cephalosporin antibotic. It has a broad spectrum bactericidal activity against a wide range of common pathogens, including b-lactamase producing strains like Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella pneumoniae, and Proteus mirabilis. As with other cephalosporins, bactericidal activity of Cefexta results from inhibition of cell wall synthesis.

The total daily dose for all infections is 600 mg. The dosage schedule is given in the following: Type of infection Dosage Duration Acute Exacerbations of Chronic Bronchitis 300  mg two times daily or 600 mg once daily 5 to 10 days Pharyngitis/Tonsillitis Acute Bacterial Otitis Media Acute Maxillary Sinusitis 300 mg two times daily or 600 mg once daily 10 days Community Acquired Pneumonia 300mg two times daily 10 days Uncomplicated Skin and Skin Structure Infections Powder for Oral Suspension : The total daily dose for all infections is 14 mg/kg body weight up to a maximum dose of 600 mg per day. The dosage schedule of oral suspension for pediatric patients as follows: Type of infection Dosage Duration Acute Bacterial Otitis Media 7mg/kg two times or 14 mg/kg once daily 5 to 10 days Phayngitis/Tonsilitis Acute Maxillary Sinusitis 7mg/kg two times or14 mg/kg once daily 10 days Uncomplicated Skin and Skin Structure Infections 7mg/kg two times daily 10 days Direction for Reconstitution of Powder for Suspension : Shake the bottle well so that powder does not clog. Add 40 ml (8 x 5 ml spoonful) boiled and cooled water with the provided 5ml spoon to the bottle. Shake well until all powder is dispersed. Reconstituted suspension should be used within 10 days of preparation if kept at room  temperature or within 14 days if kept in a refrigerator. Shake the bottle well before use.

Antacids : Adinir should be taken at least 2 hours interval of antacid administration. Iron supplement : Adinir should be taken at least 2 hours interval of iron supplement administration. Probencid : It inhibits the renal excretion of Adinir.

Cefdinir is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.

Common side effects are Diarrhea, Vaginal moniliasis, Nausea & Vomiting, Headache, Rash etc.

Its pregnancy category is B. But there are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. After administration of single 600 mg doses Cefdinir was not detected in the breast milk.

Adinir, as with other broad-spectrum antibiotics, should be prescribed with caution in individuals with a history of colitis. In patients with transient or persistent renal insufficiency (creatinine clearance <30 ml/min), the total daily dose of Adinir should be reduced.

Store at room temperature and protect from light. After reconstitution the suspension can be used within 7 days if kept at room temperature and within 14 days if kept in refrigerator (2-8°C). Always keep the bottle tightly closed.