Indications
Agoxin is indicated in:
Heart failure.
Atrial fibrillation with an uncontrolled ventricular rate.
Acute left ventricular failure.
Chronic left ventricular failure and conjestive heart failure, especially when caused by hypertensive valvular (especially mitral valvular) disease or ischaemic heart disease.
Pharmacology
Digoxin is a cardiac glycoside used in the management of particularly atrial fibrillation and in heart failure.The principal actions of digoxin are an increase in the force of myocardial contraction (positive inotropic activity and a reduction in the conductivity of the heart particularly in conduction through the atrioventricular node. Digoxin also has a direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system and particularly by an increase in vagal activity.
Dosage and administration
By oral administration:
Rapid digitalization : 1-1.5 mg in divided doses over 24 hours
Less urgent digitalization : 250-500 micrograms daily (higher dose may be divided)
Maintenance : 62.5-500 micrograms daily (higher dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
Usual range : 125-250 micrograms daily (lower dose may be divided) according to renal function and in atrial fibrilation on heart rate response.
Usual range : 125-250 micrograms daily (lower dose may be appropriate in the elderly).
Interactions
Potassium-depleting diuretics increase the effects of digitalis. Calcium particularly if administered rapidly by the intravenous route, may produce serious arrhythmia in digitalized patients. Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, spironolactone, erythromycin, clarithromycin (and possibly other macrolide antibiotics) and tetracycline increase Agoxin serum level. Besides antacids, kaolinpectin, sulfasalazine, neomycin, penicillamine, calestipol, metoclopramide, rifampin may interfere with intestinal absorption of Agoxin resulting low serum concentrations of the drug.
Contraindications
Ventricular fibrillation.
Hypersensitivity to digoxin or other digitalis preparation.
Side effects
Usually associated with excessive dosage include anorexia, nausea, vomiting, diarrhoea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block, intestinal ischaemia, gynaecomastia on long term use, thrombocytopenia reported. Agoxin can be safely used in pregnancy
Pregnancy and lactation
Digoxin is excreted in breast milk but in concentration below those found in plasma and therefore poses no hazard to the breast-fed infant.
Storage
Store in a cool and dry place.Keep out of the reach of children.
Similar brands of Digoxin
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Centoxin | Opsonin Pharma Ltd. | Tablet | 0.25 mg | ৳ 1.09per unit |
| 2 | Centoxin | Opsonin Pharma Ltd. | Oral Solution | 0.25 mg/5 ml | Not listed |
Common questions
What is Agoxin used for?
Agoxin is indicated in: Heart failure. Atrial fibrillation with an uncontrolled ventricular rate.
What is the generic name of Agoxin?
Agoxin contains Digoxin, which belongs to the group: Positive Inotropic drugs.
Who makes Agoxin?
Agoxin is marketed in Bangladesh by Aristopharma Ltd..
How much does Agoxin 0.25 mg cost?
The listed price is ৳ 1.09 per unit and ৳ 10.90 per strip. Prices can change, so check with your pharmacy.
How is Agoxin taken?
5-500 micrograms daily (higher dose may be divided) according to renal function and in atrial fibrillation on heart rate response. Usual range : 125-250 micrograms daily (lower dose may be divided) according to renal function and in atrial fibrilation on heart rate response. Always follow your doctor's instructions.
What are the side effects of Agoxin?
Usually associated with excessive dosage include anorexia, nausea, vomiting, diarrhoea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block, intestinal ischaemia, gynaecomastia on long term use, thrombocytopenia reported.
Is Agoxin safe in pregnancy?
Digoxin is excreted in breast milk but in concentration below those found in plasma and therefore poses no hazard to the breast-fed infant. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.