Indications
Aldorin tablet is indicated for the improvement of subjective symptoms (numbness and pain), abnormality of vibration sense and abnormal change in heartbeat associated with diabetic peripheral neuropathy (when high glycohemoglobin value is noted).
Pharmacology
Epalrestat specifically inhibits aldose reductase and accumulation of sorbitol in the nerve; thereby improves subjective symptoms and nerve dysfunction in patients with diabetic peripheral neuropathy.
Dosage and administration
The usual adult dose is 1 tablet (50 mg) three times daily before each meal. The dosage may be adjusted according to the patient's age and symptoms.
Interactions
There are no known drug interactions and none well documented.
Contraindications
The drug is contraindicated for patients with known hypersensitivity to epalrestat.
Side effects
Major adverse reactions are hepatic function abnormalities and thrombocytopenia. In cases of hepatic abnormalities drug should be discontinued immediately and appropriate measures should be taken. Other reactions may be malaise, headache, abdominal pain, nausea, hypersensitivity reaction etc.
Pregnancy and lactation
The safety of epalrestat in pregnant women has not been established. The drug may be used in pregnant women or in women who may possibly be pregnant only if expected therapeutic benefits outweigh the possible risks associated with the treatment. Breast-feeding should be avoided during administration of epalrestat.
Precautions and warnings
The administration of Aldorin should be considered to patients showing high glycohemoglobin values even after fundamental therapies for diabetes mellitus such as diet therapy, exercise therapy and treatment with an oral hypoglycemic agent, insulin etc. The efficacy of Aldorin has not been established in patients with diabetic peripheral neuropathy with irreversible organic changes. The patient should be carefully monitored during the administration of Aldorin. When the efficacy of Aldorin is not observed even after 12 weeks of administration, other appropriate therapies should be taken.
Storage
Do not store above 30°C temperature. Keep away from light and wet place. Keep out of reach of children.
Similar brands of Epalrestat
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Epastat | Opsonin Pharma Ltd. | Tablet | 50 mg | ৳ 10.00per unit |
| 2 | Neureliv | Incepta Pharmaceuticals Ltd. | Tablet | 50 mg | ৳ 10.00per unit |
Common questions
What is Aldorin used for?
Aldorin tablet is indicated for the improvement of subjective symptoms (numbness and pain), abnormality of vibration sense and abnormal change in heartbeat associated with diabetic peripheral neuropathy (when high glycohemoglobin value is noted).
What is the generic name of Aldorin?
Aldorin contains Epalrestat, which belongs to the group: Aldose reductase inhibitor.
Who makes Aldorin?
Aldorin is marketed in Bangladesh by Eskayef Pharmaceuticals Ltd..
How much does Aldorin 50 mg cost?
The listed price is ৳ 11.00 per unit and ৳ 110.00 per strip. Prices can change, so check with your pharmacy.
How is Aldorin taken?
The usual adult dose is 1 tablet (50 mg) three times daily before each meal. The dosage may be adjusted according to the patient's age and symptoms. Always follow your doctor's instructions.
What are the side effects of Aldorin?
Major adverse reactions are hepatic function abnormalities and thrombocytopenia. In cases of hepatic abnormalities drug should be discontinued immediately and appropriate measures should be taken.
Is Aldorin safe in pregnancy?
The safety of epalrestat in pregnant women has not been established. The drug may be used in pregnant women or in women who may possibly be pregnant only if expected therapeutic benefits outweigh the possible risks associated with the treatment. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.