Indications
Ambronil is indicated in-
Productive cough
Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis
Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus
Asthmatic bronchitis bronchial asthma with thick expectoration
Bronchiectasis
Chronic pneumonia etc.
Pharmacology
Ambroxol is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism leading to liquefaction of mucus in the lumen of respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Ambroxol has anti inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.
Dosage and administration
Average daily dose (preferably after meal): Pediatric Drops:
0-6 months : 0.5 ml 2 times a day
6-12 months : 1 ml 2 times a day
1-2 years : 1.25 ml 2 times a day
Syrup:
2-5 years : 2.5 ml (1/2 teaspoonful) 2-3 times a day
5-10 years : 5 ml (1 teaspoonful) 2-3 times a day
10 years and adults : 10 ml (2 teaspoonful) 3 times a day.
Sustained release capsule: Adult and children over 12 years old: 1 capsule once daily.
Interactions
Ambronil should not be taken simultaneously with antitussives (e.g.Codeine) because phlegm, which has been liquefied by Ambronil might not be expectorated.
Contraindications
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.
Side effects
Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema have been reported.
Pregnancy and lactation
Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the1st trimester. Safety during lactation has not been established yet.
Precautions and warnings
Ambronil should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Storage
Protect from direct light exposure, Store in a dry place at a temperature not exceeding 30°C, Keep out of the reach of children.
Similar brands of Ambroxol Hydrochloride
Common questions
What is Ambronil used for?
Ambronil is indicated in- Productive cough Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus Asthmatic bronchitis bronchial asthma with t…
What is the generic name of Ambronil?
Ambronil contains Ambroxol Hydrochloride, which belongs to the group: Cough expectorants & mucolytics.
Who makes Ambronil?
Ambronil is marketed in Bangladesh by Orion Pharma Ltd..
How is Ambronil taken?
5 ml (1/2 teaspoonful) 2-3 times a day 5-10 years : 5 ml (1 teaspoonful) 2-3 times a day 10 years and adults : 10 ml (2 teaspoonful) 3 times a day. Sustained release capsule: Adult and children over 12 years old: 1 capsule once daily. Always follow your doctor's instructions.
What are the side effects of Ambronil?
Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema have been reported.
Is Ambronil safe in pregnancy?
Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the1st trimester. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.