Indications
- It is indicated in the following infections -
- Acute bacterial exacerbation of chronic bronchitis
- Acute community acquired pneumonia
- Pharyngitis or tonsillitis
- Skin and soft tissue infections
- Urinary tract infections
- Uncomplicated gonorrhea
- Acute maxillary sinusitis
Pharmacology
Cefpodoxime is a third generation semi-synthetic Cephalosporin, exhibits activity against several Gram positive as well as Gram negative microorganisms. This compound is also stable in beta lactamase environment. Cefpodoxime exhibits exceptional activity against methicillin susceptible Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp. and Moraxella catarrhalis. Clavulanic acid is a natural inhibitor of beta lactamase which are produced by Streptomyces clavuligerus. It binds to beta lactamase moieties and inactivates them, thus restricting the Cefpodoxime destruction.
Dosage and administration
For adults (Age 12 years and older):
Acute bacterial exacerbation of chronic bronchitis : 1 tablet 12 hourly for 10 days
Acute community acquired pneumonia : 1 tablet 12 hourly for 14 days
Pharyngitis or tonsillitis : ½ tablet 12 hourly for 5 to 10 days
Skin and soft tissue infections : 2 tablet 12 hourly for 7 to 14 days
Urinary tract infections : ½ tablet 12 hourly for 7 days
Uncomplicated gonorrhea : Single dose
Acute maxillary sinusitis : 1 tablet 12 hourly for 10 days
For children: Children 2 months to 12 years- 10 mg/kg/day in divided dose, every 12 hours.
Interactions
Concomitant administration of Cefpodoxime at high doses with antacids or H2 blockers reduces peak plasma levels of Cefpodoxime.
Contraindications
Cefpodoxime is contraindicated in patients with known hypersensitivity to Cephalosporins.
Side effects
Cefpodoxime is well tolerated. Most common gastrointestinal adverse effects are diarrhea, vomiting and abdominal pain.
Pregnancy and lactation
US FDA pregnancy category of Cefpodoxime & Clavulanic Acid is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Cefpodoxime have been shown to be excreted in human milk. So, caution should be exercised when Cefpodoxime is administered to a nursing woman.
Precautions and warnings
Cefpodoxime should be administered with caution to patients receiving concurrent treatment with diuretics.
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Similar brands of Cefpodoxime Proxetil + Clavulanic Acid
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Xtabac | Opsonin Pharma Ltd. | Tablet | 200 mg+125 mg | ৳ 35.00per unit |
| 2 | Clavuran | Drug International Ltd. | Tablet | 200 mg+125 mg | ৳ 40.00per unit |
| 3 | Trioclav | Eskayef Pharmaceuticals Ltd. | Tablet | 200 mg+125 mg | ৳ 40.00per unit |
| 4 | Duo-5 | Incepta Pharmaceuticals Ltd. | Tablet | 200 mg+125 mg | ৳ 50.00per unit |
| 5 | Xtabac | Opsonin Pharma Ltd. | Tablet | 100 mg+62.5 mg | ৳ 20.00per unit |
| 6 | Clavuran | Drug International Ltd. | Tablet | 100 mg+62.5 mg | ৳ 25.00per unit |
| 7 | Duo-5 LS | Incepta Pharmaceuticals Ltd. | Tablet | 100 mg+62.5 mg | ৳ 30.00per unit |
| 8 | Combocef | ACI Limited | Tablet | 100 mg+62.5 mg | ৳ 30.09per unit |
Common questions
What is Combocef used for?
It is indicated in the following infections - Acute bacterial exacerbation of chronic bronchitis Acute community acquired pneumonia Pharyngitis or tonsillitis Skin and soft tissue infections Urinary tract infections Uncomplicated gonorrhea Acute maxillary sinusitis
What is the generic name of Combocef?
Combocef contains Cefpodoxime Proxetil + Clavulanic Acid, which belongs to the group: Third generation cephalosporins.
Who makes Combocef?
Combocef is marketed in Bangladesh by ACI Limited.
How much does Combocef 200 mg+125 mg cost?
The listed price is ৳ 50.15 per unit and ৳ 200.60 per strip. Prices can change, so check with your pharmacy.
How is Combocef taken?
For adults (Age 12 years and older): Acute bacterial exacerbation of chronic bronchitis : 1 tablet 12 hourly for 10 days Acute community acquired pneumonia : 1 tablet 12 hourly for 14 days Pharyngitis or tonsillitis : ½ tablet 12 hourly for 5 to 10 days Skin and soft tissue infections : 2 tablet 12 hourly for 7 to 14 days Urinary tract infections : ½ tablet… Always follow your doctor's instructions.
What are the side effects of Combocef?
Cefpodoxime is well tolerated. Most common gastrointestinal adverse effects are diarrhea, vomiting and abdominal pain.
Is Combocef safe in pregnancy?
US FDA pregnancy category of Cefpodoxime & Clavulanic Acid is B. There are, however, no adequate and well-controlled studies in pregnant women. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.