Indications
Ledipasvir and Sofosbuvir combination is indicated for the treatment of chronic hepatitis C (CHC) genotype 1 infection in adults.
Pharmacology
This is a fixed-dose combination tablet containing ledipasvir and sofosbuvir for oral administration. Ledipasvir is an HCV NS5A inhibitor and sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase. Following oral administration of this tablet, ledipasvir median peak concentrations were observed 4 to 4.5 hours post-dose.
Dosage and administration
Recommended dosage : One tablet (90 mg of Ledipasvir and 400 mg of Sofosbuvir) taken orally once daily with or without food Recommended treatment duration:
- Treatment-naive with or without cirrhosis: 12 weeks
- Treatment-experienced without cirrhosis: 12 weeks
- Treatment-experienced with cirrhosis: 24 weeks
A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease.
Interactions
Coadministration with amiodarone may result in serious symptomatic bradycardia. Use of Ledipasvir and Sofosbuvir combination with Amiodarone is not recommended
P-gp inducers (e.g., Rifampin, St. John’s wort): May alter concentrations of Ledipasvir and Sofosbuvir. Use of Ledipasvir and Sofosbuvir combination with P-gp inducers is not recommended
Contraindications
This combination is contraindicated in patients with Known hypersensitivity to Ledipasvir, Sofosbuvir or any other ingredient in the product.
Side effects
The most common adverse reactions (incidence greater than or equal to 10%, all grades) observed with treatment with this tablet for 8, 12, or 24 weeks are fatigue, headache, nausea, diarrhea and insomnia.
Pregnancy and lactation
Pregnancy Category B. There are no adequate and well-controlled studies with Ledipasvir and Sofosbuvir in pregnant women. Because animal reproduction studies are not always predictive of human response, this should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Ledipasvir and Sofosbuvir and its metabolites are present in human breast milk.
Precautions and warnings
Bradycardia with amiodarone coadministration: Serious symptomatic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta-blockers or those with underlying cardiac comorbidities and/or advanced liver disease. Coadministration of amiodarone with this tablet is not recommended. In patients without alternative, viable treatment options, cardiac monitoring is recommended. Use with other drugs containing sofosbuvir, is not recommended.
Storage
Keep out of the reach of children. Keep in a cool & dry place. Protect from light.
Similar brands of Ledipasvir + Sofosbuvir
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Lesovir-C | Beximco Pharmaceuticals Ltd. | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
| 2 | Twinvir | Incepta Pharmaceuticals Ltd. | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
| 3 | Sofomax Duo | ACI Limited | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
| 4 | Dualvir | Aristopharma Ltd. | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
| 5 | Soforal-LP | Beacon Pharmaceuticals PLC | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
| 6 | HopSo-LP | Drug International Ltd. | Tablet | 90 mg+400 mg | ৳ 1.00per unit |
Common questions
What is Duvir used for?
Ledipasvir and Sofosbuvir combination is indicated for the treatment of chronic hepatitis C (CHC) genotype 1 infection in adults.
What is the generic name of Duvir?
Duvir contains Ledipasvir + Sofosbuvir, which belongs to the group: Hepatic viral infections (Hepatitis C).
Who makes Duvir?
Duvir is marketed in Bangladesh by UniMed UniHealth Pharmaceuticals Ltd..
How much does Duvir 90 mg+400 mg cost?
The listed price is ৳ 1.00 per unit. Prices can change, so check with your pharmacy.
How is Duvir taken?
Recommended dosage : One tablet (90 mg of Ledipasvir and 400 mg of Sofosbuvir) taken orally once daily with or without food Recommended treatment duration: Treatment-naive with or without cirrhosis: 12 weeks Treatment-experienced without cirrhosis: 12 weeks Treatment-experienced with cirrhosis: 24 weeks A dose recommendation cannot be made for patients with… Always follow your doctor's instructions.
What are the side effects of Duvir?
The most common adverse reactions (incidence greater than or equal to 10%, all grades) observed with treatment with this tablet for 8, 12, or 24 weeks are fatigue, headache, nausea, diarrhea and insomnia.
Is Duvir safe in pregnancy?
Pregnancy Category B. There are no adequate and well-controlled studies with Ledipasvir and Sofosbuvir in pregnant women. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.