Indications
Hepavir is indicated for the treatment of chronic hepatitis B associated with evidence of hepatitis B viral replication and active liver inflammation.
Pharmacology
Lamivudine is a synthetic nucleoside analogue. Lamivudine is phosphorylated intracellularly to lamivudine triphosphate. Incorporation of the monophosphate form into viral DNA occurs by hepatitis B virus (HBV) polymerase. As a result DNA chain is terminated. Lamivudine triphosphate also inhibits the RNA and DNA-dependent DNA polymerase activities of HIV-1 reverse transcriptase (RT). Lamivudine triphosphate is a very weak inhibitor of mammalian alpha, beta, and gamma-DNA polymerases.
Dosage and administration
The recommended oral dose of Lamivudine for the treatment of chronic hepatitis B in adults is 100 mg once daily.
Interactions
Trimethoprim 160 mg / Sulfamethoxazole 800 mg once daily has been shown to increase Hepavir exposure (AUC). The effect of higher doses of trimethoprim /sulfamethoxazole on Hepavir pharmacokinetics has not been investigated.
Contraindications
Lamivudine is contraindicated in patients hypersensitive to any of the components of the product.
Side effects
Several serious adverse events reported with Hepavir (lactic acidosis and severe hepatomegaly with steatosis, post treatment exacerbations of hepatitis B, pancreatitis, and emergence of viral mutants associated with reduced drug susceptibility and diminished treatment response). Malaise, fatigue, fever, ENT infections, sore throat, nausea, vomiting, abdominal discomfort, pain, diarrhea, myalgia, arthralgia, headache, skin rashes may occur. Lactic acidosis and severe hepatomegaly with steatosis, have been reported.
Pregnancy and lactation
There is no adequate and well-controlled study in pregnant women. Lamivudine should be used during pregnancy only if the potential benefits outweigh the risks. Although it is not known if lamivudine is excreted in human milk, there is the potential for adverse effects from lamivudine in nursing infants. Mothers should be instructed not to breast feed if they are receiving lamivudine.
Precautions and warnings
Patients should be assessed before beginning treatment and during treatment with Hepavir by a physician experienced in the management of chronic hepatitis B.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Similar brands of Lamivudine [For Chronic Hepatitis B]
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Lamivir | Incepta Pharmaceuticals Ltd. | Tablet | 100 mg | ৳ 25.00per unit |
| 2 | Viradin | Healthcare Pharmaceuticals Ltd. | Tablet | 100 mg | ৳ 25.00per unit |
| 3 | Lamidin | Eskayef Pharmaceuticals Ltd. | Tablet | 100 mg | ৳ 25.30per unit |
Common questions
What is Hepavir used for?
Hepavir is indicated for the treatment of chronic hepatitis B associated with evidence of hepatitis B viral replication and active liver inflammation.
What is the generic name of Hepavir?
Hepavir contains Lamivudine [For Chronic Hepatitis B], which belongs to the group: Hepatic viral infections (Hepatitis B).
Who makes Hepavir?
Hepavir is marketed in Bangladesh by Square Pharmaceuticals PLC.
How much does Hepavir 100 mg cost?
The listed price is ৳ 25.17 per unit and ৳ 100.68 per strip. Prices can change, so check with your pharmacy.
How is Hepavir taken?
The recommended oral dose of Lamivudine for the treatment of chronic hepatitis B in adults is 100 mg once daily. Always follow your doctor's instructions.
What are the side effects of Hepavir?
Several serious adverse events reported with Hepavir (lactic acidosis and severe hepatomegaly with steatosis, post treatment exacerbations of hepatitis B, pancreatitis, and emergence of viral mutants associated with reduced drug susceptibility and diminished treatment response). Malaise, fatigue, fever, ENT infections, sore throat, nausea, vomiting, abdomin…
Is Hepavir safe in pregnancy?
There is no adequate and well-controlled study in pregnant women. Lamivudine should be used during pregnancy only if the potential benefits outweigh the risks. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.