Indications
- Indever is indicated in:
- Essential hypertension
- Angina pectoris
- Cardiac arrhythmia
- Thyrotoxicosis
- Anxiety
Prophylaxis of migraine, etc.
Pharmacology
Propranolol Hydrochloride is a B-adrenergic receptor blocking drug which is widely used in hypertension and angina pectoris. Propranolol antagonizes catecholamines at B-adrenergic receptors, thus prevents excess rate and force of contraction of the heart and decreases the excess consumption of oxygen by the heart. Propranolol is almost completely absorbed from the gastrointestinal tract, but a portion is immediately metabolized by the liver when passing through the portal circulation. Peak plasma concentration occurs in 1 to 1.5 hours after oral administration. The plasma half-life of propranolol is from 3 to 6 hours. The metabolites of propranolol are excreted through the urine.
Dosage and administration
Adult (above 18 years):
Hypertension : Initially 80 mg twice daily, may be increased at weekly intervals and then maintenance dose of 160-320 mg daily is recommended.
Angina pectoris : Initially 40 mg 2-3 times daily and then maintenance dose of 120-240 mg daily is given.
Thyrotoxicosis : 10-40 mg, 3-4 times daily is given.
Anxiety : 40 mg once daily, may be increased to three times daily.
Prophylaxis of migraine : Initially 40 mg 2-3 times daily; then maintenance dose of 80-160 mg daily is recommended.
Child (From day 1 to 18 years): Hypertension:
Neonate : 0.25-0.5 mg/kg 3 times daily, adjusted according to response.
Child 1 month : 12 years: 0.25-1 mg/kg 3 times daily, maximum dose 5 mg/kg daily in divided dose.
Child 12-18 years : initially 80 mg twice daily, maintain 160-320 mg daily.
Interactions
Patients receiving verapamil, salbutamol, Levosalbutamol, ergot alkaloids, lidocain, phenobarbital drugs should be closely observed during therapy.
Contraindications
Bronchospasm, cardiogenic shock, second or third degree heart block, diabetes mellitus etc.
Side effects
Cold extremities, lassitude, nausea, dizziness, insomnia, paresthesia etc.
Pregnancy and lactation
Pregnancy category C, should not be used in pregnant women. Propranolol is excreted in human milk. Caution should be taken when propranolol is administered to a nursing mother.
Precautions and warnings
It should be taken with caution in hepatic and renal impairment, pregnancy and lactating mother.
Storage
Store in a cool and dry place, protected from light.
Similar brands of Propranolol Hydrochloride
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Propranol | Opsonin Pharma Ltd. | Tablet | 40 mg | ৳ 1.51per unit |
| 2 | Adlock | Sonear Laboratories Ltd. | Tablet | 40 mg | ৳ 1.70per unit |
| 3 | Betacap TR | Sun Pharmaceutical (Bangladesh) Ltd. | Capsule (Timed Release) | 40 mg | ৳ 2.51per unit |
| 4 | Adlock | Sonear Laboratories Ltd. | Tablet | 10 mg | ৳ 0.50per unit |
| 5 | Indever | ACI Limited | Tablet | 10 mg | ৳ 0.51per unit |
| 6 | Propranol | Opsonin Pharma Ltd. | Tablet | 10 mg | ৳ 0.51per unit |
| 7 | Indever | ACI Limited | Tablet | 20 mg | ৳ 1.00per unit |
| 8 | Propranol | Opsonin Pharma Ltd. | Tablet | 20 mg | ৳ 1.00per unit |
Common questions
What is Indever used for?
Indever is indicated in: Essential hypertension Angina pectoris Cardiac arrhythmia Thyrotoxicosis Anxiety Prophylaxis of migraine, etc.
What is the generic name of Indever?
Indever contains Propranolol Hydrochloride, which belongs to the group: Beta-adrenoceptor blocking drugs, Beta-blockers.
Who makes Indever?
Indever is marketed in Bangladesh by ACI Limited.
How much does Indever 40 mg cost?
The listed price is ৳ 1.50 per unit and ৳ 15.00 per strip. Prices can change, so check with your pharmacy.
How is Indever taken?
Adult (above 18 years): Hypertension : Initially 80 mg twice daily, may be increased at weekly intervals and then maintenance dose of 160-320 mg daily is recommended. Angina pectoris : Initially 40 mg 2-3 times daily and then maintenance dose of 120-240 mg daily is given. Always follow your doctor's instructions.
What are the side effects of Indever?
Cold extremities, lassitude, nausea, dizziness, insomnia, paresthesia etc.
Is Indever safe in pregnancy?
Pregnancy category C, should not be used in pregnant women. Propranolol is excreted in human milk. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.