Indications
Isonil is indicated in Gastro-intestinal spasm and hypermotility, cardiospasm, esophagospasm, gastroduodenitis, spastic constipation, pylorospasm, peptic ulcer, spasm associated with carcinoma. Pain and spasm of the biliary tract. Pain and spasm of the urinary tract.
Pharmacology
Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Dosage and administration
Average adult dosage is 10 mg (2 tablets) 4 times daily for several days. Dosage may be reduced depending on patient's response or as directed by the physician.
Interactions
Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.
Contraindications
Glaucoma, obstructive uropathy (for example, bladder neck obstruction due to prospective hypertrophy), obstructive disease of the gastrointestinal tract (as in achalasia, paralytic ileus, pyloroduodenal stenosis, etc.), intestinal atony of the elderly or debilitated patient, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon, complicating ulcerative colitis, myasthenia gravis, hypersensitivity.
Side effects
Common side effects are dryness of mouth, headache, palpitations, etc.
Pregnancy and lactation
Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Precautions and warnings
Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.
Overdose
Treatment is the same as for atropine overdosage.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Similar brands of Oxyphenonium Bromide
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Antrenex | Opsonin Pharma Ltd. | Tablet | 5 mg | ৳ 1.25per unit |
| 2 | A-Spasm | ACME Laboratories Ltd. | Tablet | 5 mg | ৳ 1.44per unit |
| 3 | Antrenyl | SANDOZ (A Novartis Division) | Tablet | 5 mg | ৳ 4.00per unit |
Common questions
What is Isonil used for?
Isonil is indicated in Gastro-intestinal spasm and hypermotility, cardiospasm, esophagospasm, gastroduodenitis, spastic constipation, pylorospasm, peptic ulcer, spasm associated with carcinoma. Pain and spasm of the biliary tract.
What is the generic name of Isonil?
Isonil contains Oxyphenonium Bromide, which belongs to the group: Anticholinergics (antimuscarinics)/ Anti-spasmodics.
Who makes Isonil?
Isonil is marketed in Bangladesh by Amico Laboratories Ltd..
How much does Isonil 5 mg cost?
The listed price is ৳ 1.41 per unit. Prices can change, so check with your pharmacy.
How is Isonil taken?
Average adult dosage is 10 mg (2 tablets) 4 times daily for several days. Dosage may be reduced depending on patient's response or as directed by the physician. Always follow your doctor's instructions.
What are the side effects of Isonil?
Common side effects are dryness of mouth, headache, palpitations, etc.
Is Isonil safe in pregnancy?
Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.