Indications
Linatin is indicated in the treatment of type 2 diabetes mellitus to improve glycaemic control in adults.
As monotherapy : in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance or contraindicated due to renal impairment.
... Read more Linatin is indicated in the treatment of type 2 diabetes mellitus to improve glycaemic control in adults.
As monotherapy : in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance or contraindicated due to renal impairment.
As combination therapy : in combination with metformin when diet and exercise plus metformin alone do not provide adequate glycaemic control in combination with a sulphonylurea and metformin when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control.
Pharmacology
Linagliptin is indicated to improve glycemic control in patients with type 2 diabetes mellitus. Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon like peptide-1) and GIP (glucose dependent insulinotropic polypeptide). Thus, Linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin from pancreatic beta (β) cells in a glucose-dependent manner and decreasing the secretion of glucagon from pancreatic alpha (α) cells in the circulation.
Dosage and administration
Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly. When used in combination with a sulfonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia. Patients with renal impairment: No dose adjustment required. Linagliptin can be taken with or without a meal at any time of the day.
Interactions
Linatin is a weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4, but does not inhibit other CYP isozymes. The risk for clinically meaningful interactions by other medicinal products on Linatin is low and in clinical studies Linatin had no clinically relevant effect on the pharmacokinetics of metformin, glyburide, simvastatin, warfarin, digoxin or oral contraceptives.
Contraindications
Hypersensitivity to the active substance or to any of the excipients.
Side effects
There may be hypoglycaemia, nasopharyngitis, cough and pancreatitis in combination with metformin and sulfonylurea.
Pregnancy and lactation
Pregnancy category B. There are no adequate and well controlled studies in pregnant women. So, Linagliptin tablets should be used during pregnancy only if clearly needed. It is not known whether Linagliptin passes into breast milk or not.
Precautions and warnings
Hypersensitivity to the active substance or to any of the excipients.
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Similar brands of Linagliptin
Common questions
What is Linatin used for?
Linatin is indicated in the treatment of type 2 diabetes mellitus to improve glycaemic control in adults. As monotherapy : in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance or contraindicated due to renal impairment.
What is the generic name of Linatin?
Linatin contains Linagliptin, which belongs to the group: Dipeptidyl Peptidase-4 (DPP-4) inhibitor.
Who makes Linatin?
Linatin is marketed in Bangladesh by Delta Pharma Ltd..
How much does Linatin 5 mg cost?
The listed price is ৳ 7.00 per unit and ৳ 70.00 per strip. Prices can change, so check with your pharmacy.
How is Linatin taken?
Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly. Always follow your doctor's instructions.
What are the side effects of Linatin?
There may be hypoglycaemia, nasopharyngitis, cough and pancreatitis in combination with metformin and sulfonylurea.
Is Linatin safe in pregnancy?
Pregnancy category B. There are no adequate and well controlled studies in pregnant women. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.