Melato

Melato is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag. Insomnia : Melato helps to induce sleep in people with-

Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift)

... Read more Melato is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag. Insomnia : Melato helps to induce sleep in people with-

Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift)

Low Melato levels (such as some elderly and individuals with schizophrenia)

Children with learning disabilities who suffer from insomnia.

Osteoporosis : Melato stimulates cells called osteoblasts that promote bone growth. In Menopause : Melato helps peri- or postmenopausal women to regulate sleep patterns. Eating disorders : Melato levels may play a role in the symptoms of anorexia. Attention Deficit Hyperactivity Disorder (ADHD) : it may be effective in managing sleep disturbances in children with this condition. And Sarcoidosis

After administration, melatonin binds with its receptors. Two types of melatonin receptor subtypes - MT1 & MT2 have been identified in humans. Melatonin receptors are found in the brain and some peripheral organs. The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. Increased level of Melatonin initiates neural & endocrine signals to optimize the levels of neurotransmitters e.g. increased serotonin, increased GABA & decreased dopamine, which induces & sustains sleep, as well as, maintains the body's circadian rhythm.

Adult: Insomnia: 3-6 mg one hour before bedtime Jet lag:

0.50 to 5 mg one hour prior to bedtime at final destination or, 1 to 5 mg 1 hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival at final destination.

Eastbound travel- Take a preflight early evening treatment followed by treatment at bedtime for 4 days after arrival.

Westbound travel- Take for 4 days at bedtime when in the new time zone.

Sarcoidosis: 20 mg per day for 4 to 12 months. Depression: 0.125 mg twice in the late afternoon, each dose 4 hours apart. Difficulty falling asleep: 5 mg 3 to 4 hours before an imposed sleep period over a 4-weeks period. Children (6 months to 14 years of age) : For sleep disorders 0.30 mg/day

Antidepressant Medications : Melato reduces the antidepressant effects of desipramine and fluoxetine. In addition, fluoxetine leads to measurable depletion of Melato in people. Antipsychotic Medications : People with schizophrenia and tardive dyskinesia taking antipsychotic medications with Melato has significantly reduced mouth movements compared to those who did not take the supplements. Benzodiazepines : The combination of Melato and triazolam improves sleep quality. In addition, there have been a few reports suggesting that Melato supplements may help individuals stop using long-term benzodiazepine therapy. Blood Pressure Medications : Melato may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease Melato levels. The use of beta-blockers (propranolol, acebutolol, atenolol, labetalol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce Melato production in the body. Blood-Thinning Medications, Anticoagulants : Melato may increase the risk of bleeding from anticoagulant medications such as warfarin. Interleukin-2 : In one study of 80 cancer patients, the use of Melato in conjunction with interleukin-2 led to more tumor regression and better survival rates than treatment with interleukin-2 alone. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) : NSAIDs such as ibuprofen may reduce the levels of Melato in the blood. Steroids and Immunosuppressant Medications : People should not take Melato with corticosteroids or other medications used to suppress the immune system because the supplement may cause them to be ineffective. Tamoxifen : Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and Melato may benefit certain patients with breast and other cancers. Other Substances : Caffeine, tobacco, and alcohol can all diminish levels of Melato in the body while cocaine and amphetamines may increase Melato production.

Melatonin should not be used by patients who have autoimmune diseases.

Possible adverse effects include headache and depression. Drowsiness may be experienced within 30 minutes after taking Melato and may persist for 1 hour and thus may affect driving skills.

Information regarding safety and efficacy in pregnancy and lactation is not available.

Caffeine and fluvoxamine may increase the effects of Melato, while Melato may decrease the antihypertensive effect of nifedipine.

There is little or no evidence of any major toxicities with Melato,even at high doses.

Store below 30°C. Keep away from light. Keep all the medicine out of reach of children.