Indications
- Nikethamide is indicated in-
- Acute respiratory failure
- Respiratory depression following anesthesia
- CNS depression
Pharmacology
Nikethamide also known as nicotinic acid diethylamide is a central & respiratory stimulant. It has direct stimulatory action on CNS, increases the frequency & depth of breathing. It has no immediate impact on the cardiovascular system. It is extensively metabolized in liver. All metabolites & a small amount of unchanged drug is excreted in urine.
Dosage and administration
2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide.
Interactions
Anesthetic, sympathomimetics, MAOIs, neuromuscular blockers, bupropion.
Contraindications
Porphyria, epilepsy or other convulsive disorders, perebral oedema, airways obstruction, cerebrovascular accident, severe hypertension & ischemic heart diseases.
Side effects
Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness. Cardiovascular side effects inlude Iteration of blood pressure & cardiac arrhythmia. Over dosage may cause nausea, vomiting & diarrhoea.
Pregnancy and lactation
There are no enough adequate and controlled studies in pregnant women and nursing mothers.
Precautions and warnings
It should not used in less severe degrees of hypertension or impaired cardiac reverse & hepatic dysfunction.
Storage
Store below 25°C in a dry place, away from light.
Common questions
What is Nikethamide used for?
Nikethamide is indicated in- Acute respiratory failure Respiratory depression following anesthesia CNS depression
What is the generic name of Nikethamide?
Nikethamide contains Nikethamide, which belongs to the group: Respiratory stimulants: analeptics.
Who makes Nikethamide?
Nikethamide is marketed in Bangladesh by Jayson Pharmaceutical Ltd..
How is Nikethamide taken?
2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide. Always follow your doctor's instructions.
What are the side effects of Nikethamide?
Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness.
Is Nikethamide safe in pregnancy?
There are no enough adequate and controlled studies in pregnant women and nursing mothers. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.