Indications
- 1. Expectoration in the following diseases
- Upper respiratory inflammation (pharyngitis, laryngitis)
- Acute bronchitis
- Bronchial asthma
- Chronic bronchitis
- Bronchiectasis
- Pulmonary tuberculosis
2. Drainage in chronic sinusitis 3. Drainage in otitis media with effusion
Pharmacology
carbocisteine reduces the viscosity of non-infected secretions from mucous cells in the respiratory tract. The mucolytic action is due to two mechanisms. It breaks the disulphide bonds which cross-link certain glycoprotein molecules present in the mucus and it also alters local ionic charges, both of which factors affect the viscosity of mucus. There is also evidence that it alters the composition of mucin secreted by the respiratory mucosa, decreasing the proportion of neutral glycopeptides and increasing the sialoglycopeptides.
Dosage and administration
Adults (including elderly) : Dosage is based upon an initial dosage of 2250 mg daily in divided doses (750 mg 3 times daily), reduced to 1500 mg daily in divided doses (375 mg 4 times daily), when a satisfactory response has been obtained. Children : Normal daily dose is 20 mg/kg body weight in divided doses. 2-5 years : 62.5-125 mg 4 times daily. 6-12 years : 250 mg 3 times daily. Infants : Dosage in infants has not been established.
Interactions
Neither hazardous nor therapeutically useful interactions have been reported.
Contraindications
Contraindicated in active peptic ulceration and in patients with hypersensitivity to the drug.
Side effects
Gastrointestinal discomfort, nausea, diarrhoea, gastrointestinal bleeding, headache and skin rash may occur.
Pregnancy and lactation
Although there are no reports of teratogenic effects with carbocisteine, the drug is not recommended in the first trimester of pregnancy. No information available on the use of carbocisteine during lactation.
Precautions and warnings
No specific precaution is recommended but Nokof should be used with caution in patients with a recent history of peptic ulcer and recurrent gastrointestinal bleeding.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Similar brands of Carbocisteine
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Carbolin | Eskayef Pharmaceuticals Ltd. | Capsule | 375 mg | ৳ 2.50per unit |
| 2 | Castin | ACI Limited | Capsule | 375 mg | ৳ 2.50per unit |
| 3 | Flegnil DS | Orion Pharma Ltd. | Syrup | 250 mg/5 ml | Not listed |
| 4 | Nokof | Beximco Pharmaceuticals Ltd. | Syrup | 125 mg/5 ml | Not listed |
| 5 | Nokof DS | Beximco Pharmaceuticals Ltd. | Syrup | 250 mg/5 ml | Not listed |
| 6 | Tulsi | Euro Pharma Ltd. | Syrup | 125 mg/5 ml | Not listed |
| 7 | Mucolex DS | General Pharmaceuticals Ltd. | Syrup | 250 mg/5 ml | Not listed |
| 8 | Castin | ACI Limited | Syrup | 125 mg/5 ml | Not listed |
| 9 | Castin DS | ACI Limited | Syrup | 250 mg/5 ml | Not listed |
| 10 | Carbolin DS | Eskayef Pharmaceuticals Ltd. | Syrup | 250 mg/5 ml | Not listed |
| 11 | Carboten DS | Amico Laboratories Ltd. | Syrup | 250 mg/5 ml | Not listed |
| 12 | Mucolex | General Pharmaceuticals Ltd. | Syrup | 125 mg/5 ml | Not listed |
| 13 | Flegnil | Orion Pharma Ltd. | Syrup | 125 mg/5 ml | Not listed |
Common questions
What is Nokof used for?
1. Expectoration in the following diseases Upper respiratory inflammation (pharyngitis, laryngitis) Acute bronchitis Bronchial asthma Chronic bronchitis Bronchiectasis Pulmonary tuberculosis 2.
What is the generic name of Nokof?
Nokof contains Carbocisteine, which belongs to the group: Cough expectorants & mucolytics.
Who makes Nokof?
Nokof is marketed in Bangladesh by Beximco Pharmaceuticals Ltd..
How much does Nokof 375 mg cost?
The listed price is ৳ 2.50 per unit and ৳ 25.00 per strip. Prices can change, so check with your pharmacy.
How is Nokof taken?
Adults (including elderly) : Dosage is based upon an initial dosage of 2250 mg daily in divided doses (750 mg 3 times daily), reduced to 1500 mg daily in divided doses (375 mg 4 times daily), when a satisfactory response has been obtained. Children : Normal daily dose is 20 mg/kg body weight in divided doses. Always follow your doctor's instructions.
What are the side effects of Nokof?
Gastrointestinal discomfort, nausea, diarrhoea, gastrointestinal bleeding, headache and skin rash may occur.
Is Nokof safe in pregnancy?
Although there are no reports of teratogenic effects with carbocisteine, the drug is not recommended in the first trimester of pregnancy. No information available on the use of carbocisteine during lactation. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.