Indications
Racedot is indicated as an adjunct to rehydration therapy for the symptomatic treatment of acute secretory diarrhea.
Pharmacology
Racecadotril is a prodrug that needs to be hydrolysed to its active metabolite thiorphan. Thiorphan is an inhibitor of enkephalinase. Enkephalinase is a cell membrane peptidase located in various tissues, notably in the epithelium of the small intestine. This enzyme hydrolyses or breaks down the exogenous peptides and endogenous peptides (enkephalins). Racecadotril protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing water and electrolytes hypersecretion. Racecadotril exerts rapid antidiarrheal action, without modifying the duration of intestinal transit. Racecadotril does not produce abdominal distension.
Dosage and administration
Adults : One capsule initially regardless of the time of the day; then one capsule 3 times daily (preferable before food) untill diarrhea stops. Children (3 months to 18 years): Racecadotril is suitable for children over 3 months of age. Recommended dose is 1.5 mg/kg body weight.
If body weight less than 9 kg: 10 mg 3 times daily.
If body weight 9-13 kg: 20 mg 3 times daily.
If body weight 13-27 kg: 30 mg 3 times daily.
If body weight over 30 kg: 60 mg 3 times daily.
Maximum duration of treatment is 7 days. How to use sachet:
- Dissolve the powder in 20 ml pure water
- Stir well
- After dissolving the powder drink full suspension immediately
Interactions
No interactions with other active substances have been described in humans to date. In humans, joint treatment with Racedot and Loperamide or Nifuroxazide does not modify the kinetics of Racedot.
Contraindications
Racecadotril is contraindicated in patients who have shown hypersensitivity to its components.
Side effects
Headache, rash and erythema.
Pregnancy and lactation
Due to a lack of clinical data, Racecadotril should not be administered to pregnant or breastfeeding women.
Precautions and warnings
The administration of Racedot does not modify the usual rehydration regimens. There are limited data in patients with renal or hepatic impairment. So these patients should be treated with caution.
Overdose
No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Similar brands of Racecadotril
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Radola | ACI Limited | Capsule | 100 mg | ৳ 6.00per unit |
| 2 | Rehydril | The IBN SINA Pharmaceutical PLC | Capsule | 100 mg | ৳ 6.50per unit |
| 3 | Receca | NIPRO JMI Pharma Ltd. | Capsule | 100 mg | ৳ 8.00per unit |
| 4 | Racetril | Incepta Pharmaceuticals Ltd. | Capsule | 100 mg | ৳ 8.00per unit |
| 5 | Racetril | Incepta Pharmaceuticals Ltd. | Oral Powder | 10 mg/sachet | Not listed |
| 6 | Receca | NIPRO JMI Pharma Ltd. | Oral Powder | 10 mg/sachet | Not listed |
| 7 | Racetril | Incepta Pharmaceuticals Ltd. | Oral Powder | 30 mg/sachet | Not listed |
Common questions
What is Racedot used for?
Racedot is indicated as an adjunct to rehydration therapy for the symptomatic treatment of acute secretory diarrhea.
What is the generic name of Racedot?
Racedot contains Racecadotril, which belongs to the group: Anti-diarrhoeal.
Who makes Racedot?
Racedot is marketed in Bangladesh by Square Pharmaceuticals PLC.
How much does Racedot 100 mg cost?
The listed price is ৳ 8.03 per unit and ৳ 80.33 per strip. Prices can change, so check with your pharmacy.
How is Racedot taken?
Adults : One capsule initially regardless of the time of the day; then one capsule 3 times daily (preferable before food) untill diarrhea stops. Children (3 months to 18 years): Racecadotril is suitable for children over 3 months of age. Always follow your doctor's instructions.
What are the side effects of Racedot?
Headache, rash and erythema.
Is Racedot safe in pregnancy?
Due to a lack of clinical data, Racecadotril should not be administered to pregnant or breastfeeding women. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.