Indications
- Requin is indicated in-
- Uncomplicated, severe and complicated falciparum malaria
- Falciparum malaria resistant to other drugs
- Prevention of nocturnal muscle cramps
Alleviation of muscle cramps in Thomsen's disease.
Pharmacology
Quinine is believed to interfere with protein metabolism and inhibits nucleic acid synthesis in malarial parasites. Quinine is a highly active blood schizonticide and suppresses the asexual cycle of development of malaria parasites in the erythrocytes. It is effective both as a suppressive drug and in the over clinical attack of malaria.
Dosage and administration
Adult:
Oral: 600 mg (of quinine salt) every 8 hours for 7 days.
Parenteral: lf the patient is seriously ill quinine should be given by intravenous infusion. The adult dosage regimen for quinine by infusion is loading dose of 20 mg/kg (up to maximum 1.4 g) of quinine salt infused over 4 hours then after 8-12 hours maintenance dose of 10 mg/kg (up to maximum 700 mg) of quinine salt infused over 4 hours every 8-12 hours (until patient can swallow tablets to complete the 7 days course).
Children:
Oral: Quinine is well tolerated by children. The dosage regimen for quinine by mouth for children is 10 mg/kg (of quinine salt) every 8 hours for 7 days.
Parenteral: The dosage regimen for quinine by intravenous infusion for children is calculated on a mg/kg basis as for adult.
Pregnancy: The adult treatment doses of oral and intravenous quinine given above (including the loading dose) can safely be given to pregnant women.
Contraindications
Hypersensitivity reaction, optic neuritis, in case of black water fever etc.
Side effects
Cinchonism which includes tinnitus, headache, nausea and visual disturbances. Hematological disorders and skin reaction may occur.
Pregnancy and lactation
In pregnancy, the quinine is not necessarily contraindicated. It is considered to be safe when used in therapeutic dosage in pregnancy. It is excreted in breast milk in insignificant amount which does not discard the use in lactation.
Precautions and warnings
Severe heart disease, myasthenia gravis, diabetes mellitus, IV injection should be given slowly. Use of Mefloquine with Requin sulphate may increase the chance of side effects.
Storage
Use of Mefloquine with Requin sulphate may increase the chance of side effects.
Similar brands of Quinine Sulfate
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Kanaquine | Globe Pharmaceuticals Ltd. | Injection | 300 mg/5 ml | Not listed |
| 2 | Jasoquin | Jayson Pharmaceutical Ltd. | Injection | 300 mg/5 ml | Not listed |
| 3 | Requin | Rephco Pharmaceuticals Ltd. | Tablet | 300 mg | ৳ 3.44per unit |
| 4 | Quin | Hudson Pharmaceuticals Ltd. | Tablet | 300 mg | ৳ 3.47per unit |
| 5 | Albiquin | Albion Laboratories Limited | Tablet | 300 mg | ৳ 6.40per unit |
| 6 | Kanaquine | Globe Pharmaceuticals Ltd. | Tablet | 300 mg | ৳ 6.40per unit |
| 7 | Jasoquin | Jayson Pharmaceutical Ltd. | Tablet | 300 mg | ৳ 6.44per unit |
Common questions
What is Requin used for?
Requin is indicated in- Uncomplicated, severe and complicated falciparum malaria Falciparum malaria resistant to other drugs Prevention of nocturnal muscle cramps Alleviation of muscle cramps in Thomsen's disease.
What is the generic name of Requin?
Requin contains Quinine Sulfate, which belongs to the group: Anti-malarial drugs.
Who makes Requin?
Requin is marketed in Bangladesh by Rephco Pharmaceuticals Ltd..
How much does Requin 300 mg/5 ml cost?
The listed price is ৳ 10.20 per unit. Prices can change, so check with your pharmacy.
How is Requin taken?
Adult: Oral: 600 mg (of quinine salt) every 8 hours for 7 days. Parenteral: lf the patient is seriously ill quinine should be given by intravenous infusion. Always follow your doctor's instructions.
What are the side effects of Requin?
Cinchonism which includes tinnitus, headache, nausea and visual disturbances. Hematological disorders and skin reaction may occur.
Is Requin safe in pregnancy?
In pregnancy, the quinine is not necessarily contraindicated. It is considered to be safe when used in therapeutic dosage in pregnancy. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.