Indications
Vitamin B12 is indicated in Pernicious anemia, Vitamin B12 deficiency due to low intake from food, Thyrotoxicosis, Hemorrhage, Malignancy, Liver or kidney disease, Gastric bypass surgery, total or partial gastrectomy, Gluten enteropathy or sprue, folic acid deficiency, macrocytic anaemia.
Pharmacology
Vitamin B12 (cyanocobalamin) is required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis.
Dosage and administration
Usual Adult Dose for Pernicious Anemia Initial dose : 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing:
- 100 mcg every other day for 7 doses, then
- 100 mcg every 3 to 4 days for 2 to 3 weeks, then
- Maintenance dose: 100 to 1000 mcg monthly
Administer concomitant folic acid if needed. Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption. Usual Adult Dose for B12 Nutritional Deficiency : 25 to 2000 mcg orally daily Usual Adult Dose for Schilling Test : 1000 mcg intramuscularly is the flushing dose Usual Pediatric Dose for B12 Nutritional Deficiency : 0.5 to 3 mcg daily
Interactions
Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine, cimetidine, colchicine, K salts, methyldopa.
Contraindications
Leber's disease, tobacco amblyopia.
Side effects
Arthralgia (12%), Dizziness (12%), Headache (12%), Nasopharyngitis (12%), Anaphylaxis, Angioedema, Congestive heart failure, Peripheral vascular disease,Pulmonary edema, Diarrhea, Dyspepsia, Polycythemia vera, Sore throat, Nervousness, Rhinitis, Glossitis, Hypoesthesia
Pregnancy and lactation
Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). Lactation: Drug distributed in milk.
Precautions and warnings
Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death. Use with caution in patients with Leber optic nerve atrophy. Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia
Similar brands of Cyanocobalamin
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Cynovit | Chemist Laboratories Ltd. | IM/SC Injection | 1000 mcg/ml | Not listed |
| 2 | Cynomin | Jayson Pharmaceutical Ltd. | IM/SC Injection | 1000 mcg/ml | Not listed |
| 3 | G-Vitamin B12 | Gonoshasthaya Pharma Ltd. | IM/SC Injection | 1000 mcg/ml | Not listed |
| 4 | Cynomin | Jayson Pharmaceutical Ltd. | IM/SC Injection | 250 mcg/ml | Not listed |
Common questions
What is Vitamin B12 used for?
Vitamin B12 is indicated in Pernicious anemia, Vitamin B12 deficiency due to low intake from food, Thyrotoxicosis, Hemorrhage, Malignancy, Liver or kidney disease, Gastric bypass surgery, total or partial gastrectomy, Gluten enteropathy or sprue, folic acid deficiency, macrocytic anaemia.
What is the generic name of Vitamin B12?
Vitamin B12 contains Cyanocobalamin, which belongs to the group: Vitamin-B preparations.
Who makes Vitamin B12?
Vitamin B12 is marketed in Bangladesh by Rephco Pharmaceuticals Ltd..
How is Vitamin B12 taken?
Usual Adult Dose for Pernicious Anemia Initial dose : 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then 100 mcg every 3 to 4 days for 2 to 3 weeks, then Maintenance dose: 100 to 1000 mcg monthly Administer concomi… Always follow your doctor's instructions.
What are the side effects of Vitamin B12?
Arthralgia (12%), Dizziness (12%), Headache (12%), Nasopharyngitis (12%), Anaphylaxis, Angioedema, Congestive heart failure, Peripheral vascular disease,Pulmonary edema, Diarrhea, Dyspepsia, Polycythemia vera, Sore throat, Nervousness, Rhinitis, Glossitis, Hypoesthesia
Is Vitamin B12 safe in pregnancy?
Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.