Indications
Zervira tablet is indicated for the treatment of herpes simplex, recurrent herpes simplex and herpes zoster. Its unique mechanism of action makes it a potential alternative for patients who have developed resistance to other antiviral medications.
Pharmacology
Amenamevir works by inhibiting the viral helicase-primase complex, an enzyme essential for unwinding the viral DNA and synthesizing primers during viral DNA replication. This mechanism is distinct from traditional antiviral drugs like acyclovir and valaciclovir, which target viral DNA polymerase.
Dosage and administration
Herpes simplex : The usual adult dosage of Amenavir is 200 mg administered orally once daily after meal. Recurrent herpes simplex : 1200 mg single dose after meals within 6 hours after the appearance of the initial symptoms of recurrent herpes simplex. (Only one dose is required). Herpes zoster : The usual adult dosage of Amenavir is 400 mg administered orally once daily after meal. Use in children : There is a lack of specific clinical studies evaluating the safety and efficacy of Amenamevir in children.
Interactions
Zervira has notable interactions with certain drugs due to its metabolism via cytochrome P450 enzymes, particularly CYP3A4. Ketoconazole : As a strong CYP3A4 inhibitor, Ketoconazole significantly increases the plasma concentration of Zervira. Rifampicin :This strong CYP3A4 inducer markedly decreases Zervira levels, that could lead to reduced efficacy of Zervira. Midazolam : As a substrate of CYP3A4, Midazolam's pharmacokinetics are affected by Zervira, leading to decreased plasma levels when both are taken together. Warfarin : No significant interaction was observed between Zervira and Warfarin, a medication metabolized by CYP2C9.
Contraindications
Amenamevir is contraindicated in patients with:
Severe Renal Impairment.
A history of hypersensitivity of Amenamevir or any component of the preparation.
Side effects
Common Side Effects are Headache, Nausea, Diarrhea, Abdominal Pain, Skin Reaction, increased N-acetyl-(M>glucosaminidase and a1-microglobulin levels Serious Side Effects are Thrombocytopenia, Gingival Bleeding, Palpitations.
Pregnancy and lactation
Pregnancy : Animal studies in mice and rabbits showed no adverse effects on maternal animals or fetal development at certain doses. However, the report does not provide specific recommendations regarding the safety of Amenamevir in pregnant women. Lactation : There is no specific information about the use of Amenamevir during breastfeeding.
Precautions and warnings
Special monitoring is essential for patients with the following clinical conditions:
- Severe renal impairment
- Thrombocytopenia
- Elderly patients
Storage
Store below 30°C in a dry place. Keep all medicine out of reach of children. Keep away from light & moisture.
Similar brands of Amenamevir
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Amenavir | Square Pharmaceuticals PLC | Tablet | 200 mg | ৳ 150.00per unit |
Common questions
What is Zervira used for?
Zervira tablet is indicated for the treatment of herpes simplex, recurrent herpes simplex and herpes zoster. Its unique mechanism of action makes it a potential alternative for patients who have developed resistance to other antiviral medications.
What is the generic name of Zervira?
Zervira contains Amenamevir, which belongs to the group: Anti-viral drugs.
Who makes Zervira?
Zervira is marketed in Bangladesh by Incepta Pharmaceuticals Ltd..
How much does Zervira 200 mg cost?
The listed price is ৳ 150.00 per unit and ৳ 1.00 per strip. Prices can change, so check with your pharmacy.
How is Zervira taken?
Herpes simplex : The usual adult dosage of Amenavir is 200 mg administered orally once daily after meal. Recurrent herpes simplex : 1200 mg single dose after meals within 6 hours after the appearance of the initial symptoms of recurrent herpes simplex. Always follow your doctor's instructions.
What are the side effects of Zervira?
Common Side Effects are Headache, Nausea, Diarrhea, Abdominal Pain, Skin Reaction, increased N-acetyl-(M>glucosaminidase and a1-microglobulin levels Serious Side Effects are Thrombocytopenia, Gingival Bleeding, Palpitations.
Is Zervira safe in pregnancy?
Pregnancy : Animal studies in mice and rabbits showed no adverse effects on maternal animals or fetal development at certain doses. However, the report does not provide specific recommendations regarding the safety of Amenamevir in pregnant women. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.