Indications
Zocil is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication, also known as vascular claudication, is a symptom that describes muscle pain (pain, cramps, numbness, or a feeling of fatigue) during light exertion.
Pharmacology
Cilostazol is a preparation of Cilostazol which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Dosage and administration
The recommended dosage of Cilostazol is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem. Pediatric use: The safety and effectiveness of Cilostazol in pediatric patients have not been established.
Interactions
Pharmacokinetic studies have demonstrated that Omeprazole and Erythromycin significantly increased the systemic exposure of Zocil and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of Zocil among patients concurrently treated with Diltiazem.
Contraindications
Cilostazol is contraindicated in patients with congestive heart failure of any severity. Cilostazol is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
Side effects
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Pregnancy and lactation
There are no adequate and well controlled studies in pregnant women. Transfer of Cilostazol into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Cilostazol.
Precautions and warnings
Zocil should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Zocil and Clopidogrel.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Similar brands of Cilostazol
| # | Brand | Company | Form | Strength | Price |
|---|---|---|---|---|---|
| 1 | Vasocil | The IBN SINA Pharmaceutical PLC | Tablet | 50 mg | ৳ 7.00per unit |
| 2 | Inclaud | ACI Limited | Tablet | 100 mg | ৳ 10.00per unit |
| 3 | Vasocil | The IBN SINA Pharmaceutical PLC | Tablet | 100 mg | ৳ 12.00per unit |
| 4 | Zocil | Beximco Pharmaceuticals Ltd. | Tablet | 100 mg | ৳ 12.00per unit |
| 5 | Claudinil | Incepta Pharmaceuticals Ltd. | Tablet | 100 mg | ৳ 12.00per unit |
| 6 | Pancil | Drug International Ltd. | Tablet | 100 mg | ৳ 12.00per unit |
| 7 | Cilosta | Square Pharmaceuticals PLC | Tablet | 100 mg | ৳ 12.09per unit |
Common questions
What is Zocil used for?
Zocil is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication, also known as vascular claudication, is a symptom that describes muscle pain (pain, cramps, numbness, or a feeling of fatigue) during light exertion.
What is the generic name of Zocil?
Zocil contains Cilostazol, which belongs to the group: Peripheral Vasodilator drugs: Intermittent Claudication.
Who makes Zocil?
Zocil is marketed in Bangladesh by Beximco Pharmaceuticals Ltd..
How much does Zocil 50 mg cost?
The listed price is ৳ 7.00 per unit and ৳ 70.00 per strip. Prices can change, so check with your pharmacy.
How is Zocil taken?
The recommended dosage of Cilostazol is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem. Always follow your doctor's instructions.
What are the side effects of Zocil?
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Is Zocil safe in pregnancy?
There are no adequate and well controlled studies in pregnant women. Transfer of Cilostazol into milk has been reported in experimental animals. Ask your doctor before using it while pregnant or breastfeeding.
This page is general information and is not medical advice. It does not replace a registered doctor, and it is not a prescription or a recommendation to use any medicine or test. Prices are listed prices and may change. Always follow the advice of your doctor or pharmacist.