PTX

• PTX is indicated in-
• Ascariasis
• Hookworm infections

Effective against Enterobius vermi-cularis, Trichuris trichiura, Strongyloide stercoralis and Trichostrongylus colubriformis etc.

Levamisole is the active laevo-isomer of tetramisole. It works by paralysing susceptible intestinal worms which are then excreted from the intestines. Levamisole also enhances cellular immune responses in humans.

The following doses of Levamisole are given as a single administration, preferably after a light meal.

Age 1-4 year : 1 Tablets or 5 ml Syrup

Age 5-15 year : 2 Tablets or 10 ml Syrup

Age 16 year and over : 3 Tablets or 15 ml Syrup

In cases of severe hookworm infection it is suggested that a second standard dose be given one or seven days after the first, whichever timing is feasible.

May increase toxicity of phenytoin. Increases bioavailability of ivermectin; decreases bioavailability of albendazole. Alcohol causes disulfiram-like reaction.

It is contraindicated in patients hypersensitive to Levamisole. Levamisole should not be given during pregnancy.

Side effects are infrequent. They are usually mild and transient and include nausea, vomiting, abdominal pain, giddiness (dizziness) and headache. An encephalopathy like syndrome has been reported to have occurred in a few patients two or three weeks after treatment.

Although studies in animals have shown that Levamisole produces no teratogenic effects, current medical practice requires that the benefits of any drug used during pregnancy should be weighed against the possible dangers.

Effect on ability to drive or operate machinery : There is no evidence to suggest that PTX , used for anthelmintic purpose, will produce sedation. Mild and transient giddiness is an infrequent side-effect of treatment. No precautions are suggested concerning the ability to drive or operate machinery. In case of concurrent microfilaraemia transient fever may occur.

Keep all medicines out of reach of children. Store in a cool and dry place protected from light